Primary Ovarian Insufficiency (POI) in Adolescent Female With Isochromosome 18P
نویسندگان
چکیده
منابع مشابه
A rare chromosomal disorder - isochromosome 18p syndrome.
BACKGROUND Tetrasomy 18p is a very rare chromosomal disorder and is the result of a spontaneous mutation early in embryonic development in most of the cases. This condition is characterised by the presence of a supernumerary 18p isochromosome (i(18p)) in all or some cells of the affected individual. It has a prevalence of 1/180000 live births and affects both genders equally. MATERIALS AND ME...
متن کاملAssociation of miR-938G>A Polymorphisms with Primary Ovarian Insufficiency (POI)-Related Gene Expression
MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to investigate whether polymorphisms in miR-938 are associated with the risk of primary ovarian insufficiency (POI) and POI-related target gene regulation. We identified the miR-938G>A polymorphisms within the seed sequence of mature miRNA and aligned the seed sequence with the 3'...
متن کاملPrimary Ovarian Insufficiency
Primary ovarian insufficiency or premature menopause is one of the stressful problems in women younger than 40, which may cause numerous early or late psychological and physical complications. Failure of germ cell development is associated with complete ovarian insufficiency, while their decreased number is more likely associated with partial ovarian insufficiency, which leads to secondary amen...
متن کاملPrimary Ovarian Insufficiency
From the Integrative Reproductive Medi cine Unit, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Hu man Development, National Institutes of Health, Bethesda, MD. Address reprint requests to Dr. Nelson at the Integrative Reproductive Medicine Unit, NICHD– Intramural Research Program on Repro ductive and Adult Endocrinology, CRC, Rm....
متن کاملUpdate on primary ovarian insufficiency.
PURPOSE OF REVIEW Despite an incidence of 1% among women under the age of 40, primary ovarian insufficiency (POI) is still poorly understood. As the variable cause and presentation of POI complicate its management, a standard regimen for treatment remains to be established. However, emerging research has provided new insight on current mainstays of treatment as well as novel management approach...
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ژورنال
عنوان ژورنال: Journal of Pediatric and Adolescent Gynecology
سال: 2017
ISSN: 1083-3188
DOI: 10.1016/j.jpag.2017.03.060